Electrocatalytic N-Sulfonylated Azoles

Metal-Free, Mild Conditions

An electrochemical approach that directly couples azoles with sulfonyl hydrazides to form N-sulfonylated azoles without metal catalysts, under mild conditions, suitable for late-stage modification of complex molecules.

Cheng, Huang · Chen, Kang · Hong-Jun, Liu · Chen-Lu, Wang · Sheng, Tang · Yu-Shu, Qin · Zhenhong, Wei · Cai, Hu

Green Chemistry 2024

Advantages

>70 substrate examples

Gram-scale synthesis

Electrochemical continuous-flow reaction