GABA-independent
Mechanical forces directly activate GABA_B receptors without the neurotransmitter GABA, mediating astrocyte remodeling.
Huo, Yujia · Zhou, Yiwei · Lin, Li · Yang, Fan · Meng, Jiyong · He, Feiteng · Zhang, Fengfan · Shen, Cangsong · Liu, Yuxuan · Xu, Chanjuan · Xu, Shawn X.Z. · Liu, Jianfeng
Nature Communications 2025
Shear stress promotes integrin binding to GB1
Induces allosteric rearrangement of GABA_B receptor transmembrane domains towards an active conformation
Shear stress-induced GABA_B receptor activation plays a crucial role in astrocyte remodeling