Restore Autophagy Flux
Stabilizing Beclin1 K117 dimethylation via fumarate to release BCL-2 inhibition and restore autophagy, suppressing liver tumor growth.
Wang, Lei · Shi, Runze · Wang, Shuo · Yuran, Duan · Wang, Zheng · Zheng, Peixiang · Sun, Xue · Guimei, Ji · Yuli, Shen · Bofei, Dong · Lin, Yanni · Wen-Ting, Zhao · Tian, Qi · Shiqi, Wu · Xiao, Ling · Li, Min · Liwei, Xiao · Wu, Qingang · Meng, Ying · Bai, Xueli · Liu, Tong · Zhang, Zhiren · Zhan, Peng · Lu, Zhimin · Xu, Daqian
Nature Chemical Biology 2025
Blocking ADSL-Beclin1 axis inhibits autophagy induced by lipid deprivation and ER stress
Blunts liver tumor growth in mice
ADSL pS140-upregulated Beclin1 K117me2 levels positively correlate with autophagy levels in HCC patients
ADSL pS140-upregulated Beclin1 K117me2 levels correlate with poor patient prognosis