13-fold biosynthetic boost
Splitting the large polyketide synthase gene into separate subunits rescues translation of truncated mRNAs, increasing butenyl-spinosyn PKS efficiency by 13-fold.
Liu, Yan · Song, Chaoyi · Cui, Qingwen · Sun, Hongluan · Jiang, Chanjuan · Ruofei, Guo · He, Ruoting · Li, Zhen · Luan, Ji · Wang, Hailong
Nature Communications 2025