Dual-source copper remodels TME
A folate-modified liposomal nanoplatform co-loading copper peroxide and chloroquine that orchestrates endogenous and exogenous copper for efficient catalysis, synergizing with anti-PD-L1 to boost chemoimmunotherapy.
Daxi, Sun · Yu, Liting · Wang, Gang · Xu, Yuxue · Wang, Peng · Wang, Ningning · Wu, Zhengyan · Zhang, Guilong · Zhang, Jia · Zhang, Yunjiao · Tian, Geng · Wei, Pengfei
Journal of Nanobiotechnology 2024
Significantly induces intratumoral dendritic cells and CD8+ T cell infiltration
Long-term high-level existence of immunogenic cell death markers
Significant anti-tumor effect when combined with anti-PD-L1