15× Longer Half-Life
Molecular modification mediated by an intrinsically disordered protein extends circulation half-life while preserving high binding affinity and avoiding heterogeneous byproducts.
Bo, Jia · Gu, Xinquan · Shen, Siyu · Liu, Yangyi · Ming, Li · Wei, Zheng · Yao, Sun · Ma, Chao · Wang, Fan · Su, Juanjuan · Zhang, Hongjie · Li, Jingjing · Wei, Wei · Liu, Kai
Advanced Functional Materials 2024
Submicromolar IC50 against pseudotyped SARS-CoV-2 variants, comparable to unmodified nanobodies
In vivo therapeutic efficacy toward breast cancer significantly enhanced