Gel-Microsphere Sequential-Release Scaffold

Guides Endogenous Bone Regeneration

Dual-network hydrogel with microspheres sequentially releases chondroitin sulfate and ions to guide stem cell differentiation along the endochondral ossification pathway.

Wang, Xinyu · Dai, Wenli · Gao, Chenyuan · Zhang, Liwen · Wan, Zhuo · Wang, Yue · Tang, Yujing · Yu, Yingjie · Yang, Xiaoping · Cai, Qing

ACS Applied Materials & Interfaces 2023

Advantages

Sequential release of chondroitin sulfate and Mg/Si ions

In vitro and in vivo evaluations confirm enhanced bone regeneration