Uncovers Immune-Regulatory Mutations
A base editor library for massive parallel screening of functional variants in cancer immunosurveillance, covering genes regulating both PD-L1 and HLA-I.
Liu, Ying · Liu, Yongshuo · Niu, Xuran · Chen, Ang · Li, Yizhou · Yu, Ying · Liu, Zhiheng · Xu, Tao · Cheng, Jie · Wu, Zeguang · Wei, Wensheng
Signal Transduction and Targeted Therapy 2025
~820,000 sgRNAs
Targets all feasible serine/threonine/tyrosine residues across the human genome
Identified thousands of novel mutations