Nanobody-Catalyst Conjugate

PD-L1-targeted prodrug activation

A bifunctional conjugate integrating PD-L1 blockade and bioorthogonal catalytic activation enables localized chemotherapeutic release with reduced toxicity and enhanced immune responses.

Zhao, Zhennan · Wang, Xinyu · Wang, Jinhui · Li, Yiyi · Lin, Wenkai · Lu, Kai · Chen, Jun · Xia, Wei · Mao, Zongwan Wang

Journal of Medicinal Chemistry 2023

Specifications

细胞增加

{'zh': '49.7', 'en': ''} %

肿瘤生长抑制

{'zh': '67.7', 'en': ''} %

Advantages

Exhibits high antitumor activity and low cytotoxicity in murine models