Relieves key inhibition
Import of miR5298b relieves the inhibition of taxol biosynthesis by the TcNPR3-TcTGA6 complex, providing a new route to high-yield Taxus material.
Chen, Ying · Zhang, Meng · Zhang, Wenli · Wang, Yamin · Zhang, Hua · Liu, Yang · Yu, Longjiang · Fu, Chunhua
International Journal of Biological Macromolecules 2023
miR5298b promoted taxol accumulation in transient leaf overexpression experiments
miR5298b upregulated taxol biosynthesis genes including DBAT, TASY, and T5H
TcNPR3 repressed taxol biosynthesis
TcTGA6 directly binds the TGACG motif in promoters of TASY, T5H, and T10H to negatively regulate taxol biosynthesis