Vacuolar sequestration detox
Unlike typical MTPs, SgMTP1 localizes to the tonoplast and detoxifies excess Mn by vacuolar sequestration, enhancing tolerance without efflux.
Wang, Wenqiang · Linjie, Wang · Jia, Yidan · Liu, Pandao · Chen, Zhijian
Plant Physiology and Biochemistry 2025
SgMTP1 expression specifically rescued Mn hypersensitivity in yeast mutant Δpmr1
Transgenic composite plants overexpressing SgMTP1 showed increased shoot and root dry weight under Mn toxicity
Site-directed mutagenesis identified 13 residues critical for SgMTP1-mediated Mn transport