Activatable NIR-II Fluorescent Probe AFP2

Linrong, Chen; Ouyang, Yanni; Chen, Jian; Li, Haoze; Wu, Min; Qu, Rui; Zhou, Wenya; Zhang, Chunfeng; Wu, Wei; Jiang, Xiqun; Zhen, Xu

Activatable NIR-II Fluorescent Probe AFP2

Early detection of DILI

Achieves high signal-to-background activation via engineered excited-state charge transfer dynamics, enabling early diagnosis of drug-induced liver injury and detection of tiny metastatic foci.

Linrong, Chen · Ouyang, Yanni · Chen, Jian · Li, Haoze · Wu, Min · Qu, Rui · Zhou, Wenya · Zhang, Chunfeng · Wu, Wei · Jiang, Xiqun · Zhen, Xu

Journal of the American Chemical Society 2025

Specifications

tiny metastatic foci: {'zh': '< 2', 'en': '< 2'} mm

Advantages

Early diagnosis of drug-induced liver injury

Superior sensitivity outperforming conventional methods