Cu-catalyzed quinazolinones

Solvent-switched synthesis

Using o-aminobenzamide as a C1 source, two classes of quinazolinone scaffolds are accessed with high selectivity simply by switching the solvent.

Min, Wang · Ke-Xin, Li · Jiaao, Xue · Kewei, Hu · Duoluo, Guo · Cai, Qun

Tetrahedron 2025

Advantages

Gram-scalable assembly

High yields

o-Aminobenzamide as an unprecedented C1 source