High spikiness
The spike structure induces mitochondrial damage and metabolic disorder, serving as a shape-dependent toxicity benchmark for nanomaterial screening.
Zhang, Rui · Li, Dan · Zhao, Ruibo · Luo, Dandan · Hu, Yeting · Shengyan, Wang · Zhuo, Xiaolu · Iqbal, Zubair M. · Zhang, Han · Han, Qianqian · Kong, Xiangdong
Journal of Nanobiotechnology 2024
GNBs with higher spikiness and tip curvature exhibited more significant cytotoxicity compared to rounded GNSs
The spike structure leads to mitochondrial damage, oxidative stress, and metabolic disorder in Hep-orgs
Similar trends were observed in HepG2 cells and mice models