HBx 2-21 Peptide

Derepresses transcription

This peptide binds Spindlin1, relieving its own transrepression and switching cccDNA chromatin from a repressive to an active state to enhance HBV transcription.

Liu, Wei · Yao, Qiyan · Su, Xiaonan · Deng, Yafang · Yang, Mo · Peng, Bo · Zhao, Fan · Du, Chao · Zhang, Xiulan · Zhu, Jinsong · Wang, Daliang · Li, Wenhui · Li, Haitao

Nature Communications 2023

Advantages

HBx 2-21 peptide binds Spindlin1 Tudor 3

Enhances histone H3 "K4me3-K9me3" readout

Promotes gene expression from cccDNA minichromosome

Epigenetic switch from H3K9me3-enriched repressive to H3K4me3-marked active state