Long-acting anti-inflammatory recombinant uricase

Urate-lowering and anti-inflammatory

Extended half-life via IL-1Ra and ABD fusion, effectively alleviating MSU crystal-induced inflammation.

Zhang, Ziyang · Fu, Nanyan · Li, Qinkai · Quan, Junming Min

Biochemical and Biophysical Research Communications 2023

Advantages

Longer in vivo half-life compared to wild-type AgUox

Significantly alleviates MSU crystal-induced inflammation in mouse model