Self-assembled Cu-chlorin e6 nanosonosensitizer

Synergistic cuproptosis and ferroptosis

Carrier-free coordination self-assembly that integrates cuproptosis and ferroptosis upon sonodynamic activation, offering a new strategy for glioblastoma therapy.

Zhu, Yang · Niu, Xuegang · Chengyu, Ding · Lin, Yuangxiang · Fang, Wenhua · Yan, Lingjun · Cheng, Junjie · Zou, Jianhua · Yu, Tian · Huang, Wei · Huang, Wen · Pan, Yuanbo · Wu, Tiantian · Xiaoyuan, Chen · Dezhi, Kang

Advanced Science 2024

Advantages

Significant blood-brain barrier penetration and tumor accumulation

Sonodynamic-triggered combination of ferroptosis and cuproptosis verified in vitro and in vivo

Minimal side effects in vivo