Pd-Catalyzed Isoquinolinone Synthesis

One-step bicyclic construction

This catalytic system assembles isoquinolinone scaffolds from simple starting materials via a unique [3+2+1]/[4+2] heteroannulation cascade, offering a novel strategy for N-heterocycle synthesis.

Xue, Qi · Li, Yang · Sun, Fujin · Hu, Ming · Cai, Hu · Li, Jinheng

Chinese Journal of Chemistry 2025

Advantages

Excellent selectivity

Good functional group compatibility

Broad substrate scope