Axially Chiral Naphthylpyrroles

High Enantioselectivity

Constructed via copper-catalyzed diyne cyclization, these compounds provide an efficient non-diazo route to axially chiral frameworks, with derived chiral phosphine ligands applicable to asymmetric catalysis.

Cui, Li · Qi, Lin · Gao, Liu · Lu, Xin · Ye, Longwu · Zhou, Bo

Nature Communications 2023

Specifications

产率最高可
{'zh': '99', 'en': ''} %
对映体过量最高可
{'zh': '99', 'en': ''} %