Deep Tumor Penetration
Small-sized HfO₂ nanoparticles exhibit more homogeneous distribution, faster diffusion, and deeper penetration in tumors, further enhanced by low-dose X-ray irradiation.
Wang, Jiali · Zhang, Tingfeng · Liao, You · Wei-Wei, Chen · Liang, Shanshan · Xu, Si · Hao, Fang · Wang, Meng · Zheng, Lingna · Gu, Zhanjun · Zhang, Zhiyong · Wang, Bing · Bi, Yi · Feng, Weiyue
Analytica Chimica Acta 2023
2 nm HfO₂ NPs diffused into tumor tissues at 2 h post-injection
50 nm HfO₂ NPs diffused into tumor tissues at 2 h post-injection
At day 7 after low-dose X-ray irradiation, both HfO₂ NPs sizes showed obvious increase in tumor penetration and distribution area