Remolds SCI microenvironment
A photosensitive hydrogel scaffold binary-modified with genetically engineered SDF1α and NT3 remodels the lesion microenvironment to promote endogenous neural stem cell migration, neuronal differentiation, and synaptic network reconstruction.
Liu, Dingyang · Shen, He · Zhang, Kai · He, Xinghui · Long, Ge · Li, Xing
Advanced healthcare materials 2023
Short-term: induced nestin+ neural stem cell migration and neuronal differentiation
Long-term: promoted neuronal maturation, functionalization, and synaptic network reconstruction
Animal model: exhibited better improvement in motor functions