Activates FGF21 to ameliorate ALD
This small molecule activates FGF21 production and secretion, inhibiting hepatic lipogenesis and offering a new therapeutic strategy for alcohol-associated liver disease.
Jiang, Yang · Lin, Liangcai · Xiao, Dongguang · Wan, Qin · Li, Yu · Zhang, Cuiying
Advanced Science 2024
Mimics lipogenesis lowering effects by stimulating FGF21
Ethyl lactate-mediated beneficial effects abolished by SIRT1 inhibition with EX527
FGF21 deficiency in hepatocytes blocks downregulation of lipogenesis by ethyl lactate