Mesoporous Polydopamine Nanocarrier

Sensitizes oxidative-photothermal therapy

This single carrier simultaneously enables photothermal heating, ROS generation, and glutathione depletion in tumors, providing an integrated platform for combined oxidative and photothermal therapy.

Zhang, Meng · Ran, Siyi · Yin, Xueling · Zhang, Jiting · Sun, Xiao · Wei, Sun · Zhu, Zhihong

BMEMat 2023

Advantages

Mesoporous polydopamine nanoplatform loaded with calcium ascorbate

Promotes H₂O₂ production at tumor site

Depletes glutathione

Significantly enhanced antitumor activity in vitro and in vivo