More potent and stable
Disulfide surrogates of H2 relaxin constructed via an intermolecular native chemical ligation-assisted diaminodiacid strategy; one analog exhibits improved potency, selectivity, and stability over native H2 relaxin.
Zhao, Rui · Shi, Pan · Xiong, Wei · Zhemin, Xia · Shi, Chaowei · Shi, Jing
Organic Letters 2023
Four new H2 relaxin analogs synthesized
H2-2a-B28Ile exhibits improved potency, selectivity, and stability compared with native H2 relaxin