Lysosome-Triggered Nanotherapy

Anti-Resorptive & Pro-Anabolic

A liposome-based nanotherapy that converts osteoclast death into apoptotic bodies carrying pro-anabolic lipids, simultaneously suppressing bone resorption and promoting bone formation.

Chen, Peng · Zhengrong, Chen · Zhang, Jie · Dai, Qijie · Tan, Jiulin · Guo, Shuquan · Luo, Fei · Dou, Ce

Pharmacological Research 2026

Advantages

Significantly improved bone mineral density and trabecular architecture in ovariectomized mice

Significantly increased osteopontin expression

Significantly expanded CD31⁺/EMCN⁺ vasculature