Photodynamic Cationic Liposomes

PDT eradicates MRSA biofilms

Cationic liposomes loaded with ultrasmall copper oxide nanoparticles penetrate MRSA biofilms and eradicate them via synergistic photodynamic and metal-based killing.

Chen, Xiangjun · Li, Wenting · Xueling, Li · Li, Keke · Zhang, Guilong · Hong, Wei

International journal of nanomedicine 2023

Advantages

Minimal toxicity to mammalian cells

Significantly enhanced association affinity with MRSA

Effectively eliminated biofilms under light irradiation

Significant antibacterial effects and abscess healing in MRSA-infected mice