Cyclometalated Ru(II) Complexes

Induces Reductive Damage

Possesses SOD activity to lower ROS and induce HeLa apoptosis, offering an option for cisplatin-resistant tumors

Zhu, Xiudeng · Sun, Qiang · Guo, Xinhua · Liang, Chunmei · Zhang, Yao · Huang, Wenlong · Huang, Zunnan · Chen, Lanmei · Chen, Jincan

Journal of Inorganic Biochemistry 2023

Advantages

Inhibits HeLa cell proliferation

Mitochondrial abnormalities

DNA damage

RuβC-7 exhibits SOD activity and lowers intracellular ROS