PROTAC 10

High-cooperativity antiviral degradation

A PROTAC molecule targeting SARS-CoV-2 RdRp, achieving high cooperativity and effective degradation via optimized linker and E3 ligand.

Kiran, Shehzadi · Iqra, Kalsoom · Dong, Jingyue · Gao, Peifeng · Irfan, Muhammad · Yu, Mingjia · Meng, Zihui · Liang, Jian

Journal of Medicinal Chemistry 2025

Specifications

Kd

{'zh': '1.09', 'en': '1.09'} nM

DC

{'zh': '1.97', 'en': '1.97'} μM

IC

{'zh': '3.12', 'en': '3.12'} μM

Advantages

α = 45.9