Dual-target sequential delivery
A DNA-assembled dissociable nanoparticle that releases two drugs in the tumor microenvironment to synergistically enhance antitumor immunity and overcome checkpoint resistance.
Zhou, Yanfeng · Guo, Daoxia · Ji, Xiaoyuan · Chen, Nan · Song, Haiyun
Advanced Materials 2024
Assembly via interparticle DNA annealing; dissociation triggered by tumor microenvironment strand separation
Induces endogenous retrovirus expression and immunogenic cell death in tumor cells
Synergistically promotes dendritic cell maturation and CD8+ T cell activation
Overcomes tumor resistance to immune checkpoint blockade therapy