Sustained Anti-inflammatory Release
This hydrogel delivery system significantly suppresses chemokine expression in gingival fibroblasts, offering a novel approach for periodontitis treatment.
Panahipour, Layla · Zhang, Yan · Li, Lingli · Gruber, Reinhard
International Journal of Molecular Sciences 2024
Significantly reduced expression of CXCL8, CXCL1, CXCL2, and CCL2 in gingival fibroblasts
Lowered phosphorylation of ERK and JNK without affecting cell viability
Greatly diminished forced chemokine expression in HSC2 oral squamous epithelial cells
DMF-enriched gellan gum hydrogels significantly reduced forced chemokine expression in gingival fibroblasts in coculture