Mucosal nanovaccine

Potent infection blockade

Assembled with maltodextrin, PEI and 2',3'-cGAMP as adjuvants and RBD trimer antigen, inducing comprehensive and durable mucosal and systemic immune responses.

Tian-Tian, Yu · Qi, Jinming · Shen, Lijuan · Wang, Guosheng · Yu, Weili · Hu, Tao

International Journal of Biological Macromolecules 2025

Advantages

Elicited strong serum RBD-specific IgG and IgA responses

Elicited strong neutralizing antibody responses

Elicited high ACE2-blocking activity

Elicited durable RBD-specific memory T cell and B cell responses