Imidazole-Based Multicompartment LNPs

Potent mRNA/siRNA codelivery

Unique sponge-like disordered internal structure enables efficient nucleic acid encapsulation and delivery, activating both innate and adaptive immunity for synergistic anti-AML effects.

Xin, Xiaofei · Wu, Di · Ding, Yu · Tian, Qiang · Qin, Chao · Li, Na Na · Yin, Linfang

Journal of the American Chemical Society 2026

Advantages

Codelivers mRNA and STAT3-targeting siRNA

Restores DC antigen presentation in AML

Reverses T cell exhaustion and enhances NK cell antileukemic activity