Promotes cytosolic MDM2-NDUFS1 binding
A p53-independent MDM2 molecular glue that disrupts mitochondrial homeostasis via cytosolic MDM2-NDUFS1 binding, triggering the integrated stress response.
Wang, Rui · Gao, Yuan · Pan, Di · Guo, Yongjian · Wei, Libing Bin
Journal of Advanced Research 2026
Binds NDUFS1, inhibits electron transport chain complex I formation
Disrupts mitochondrial homeostasis (altered membrane potential, superoxide, ATP generation, oxygen consumption rate)
Activates OMA1-DELE1 signaling axis
Induces integrated stress response-triggered apoptosis