Ferroptosis-synergized immunotherapy
Combined with intratumoral implanted micromagnets, actively enriched via internal magnetic field, overcoming apoptosis and immunotherapy resistance in prostate cancer.
Wang, Hui · Guan, Yu · Li, Chun · Chen, Jia · Shaoyu, Yue · Qian, Jieying · Dai, Bangshun · Jiang, Changqin · Wen, Chenghao · Wen, Longping · Liang, Chaozhao · Zhang, Yunjiao · Zhang, Li
Small 2023
Intratumoral implanted micromagnets establish internal magnetic field, leading to high-efficiency accumulation of intravenously injected PMZFNs in prostate cancer
Induce potent ferroptosis, directly suppressing prostate cancer
Ferroptosis triggers burst release of cancer-associated antigens, initiating immunogenic cell death (ICD)
Activate cGAS-STING pathway, generating interferon-β to further amplify ICD efficacy
Negligible systemic toxicity