Essential for 18S rRNA Maturation
DDX10 ensures 18S rRNA maturation by controlling U3 snoRNA release from pre-rRNA; its loss disrupts small ribosomal subunit biogenesis.
Wang, Xiuqin · Wang, Lisha · YanJiang, Liu · Shengxiong, Yang · Zhao, Qian · Huang, Qiuling · Wang, Wentao · Guo, Wenjing · Li, Heying · Song, Yawei · Cai, Qingqing · Zhang, Xiaofei · Wang, Xiangting · Chen, Yueqin · Yao, Hongjie
Nature Communications 2024
DDX10 degradation prevents U3 snoRNA release from pre-rRNA
NUP98-DDX10 fusion alters DDX10 localization and ablates pre-rRNA processing regulation