Induces Neuronal Apoptosis
Triggers hippocampal neuronal apoptosis via ROS-Drp1 mitochondrial fission axis, with toxicity primarily particle-specific rather than from released silver ions.
Chang, Xiaoru · Niu, Shuyan · Shang, Mengting · Li, Jiangyan · Menghao, Guo · Zhang, Wenli · Sun, Zuoyi · Li, Yunjing · Zhang, Rui · Shen, Xin · Tang, Meng · Xue, Yuying
Redox Biology 2023
Promotes mitochondrial fragmentation at 8 μg/mL for 24 h
Induces mitochondria-dependent apoptosis at 8 μg/mL for 24 h
Significantly increases Drp1 and Fis1 protein expression
Neurotoxicity mainly particle-specific rather than released ions