High-column-efficiency screening
Immobilized mitochondrial membrane overexpressing CPT1A enables rapid identification of lipid metabolism modulators, overcoming the single-target limitation of conventional screening.
Di Wu, Su · Xu, Fanding · Zhong, Jinjin · Li, Hua · Yang, Zhiwei · Ge, Shuai · He, Huaizhen · Han, Shengli · Xie, Xiuying · Guo, Hui · He, Langchong · Yi, Tao · Kong, Yu · Long, Jiangang
ACS Applied Materials & Interfaces 2024
Identified 5 CPT1A activators from Scutellariae Radix and Polygoni Cuspidati Rhizoma et Radix: baicalin, baicalein, wogonoside, wogonin, resveratrol
Resveratrol is a novel CPT1A agonist