Nucleolar RPL22 protein

Hong-Yu, Li; Wang, Min; Jiang, Xiaoyu; Wu, Zeming; He, Yifang; Yan, Kaowen; Sun, Shuhui; Ma, Shuai; Ji, Zhejun; Wang, Si; Qu, Jing; Zhang, Weiqi; Wei, Taotao; Liu, Guanghui

Nucleolar RPL22 protein

Senescence driver

Targeting nucleolar RPL22 stabilizes heterochromatin and delays cellular senescence.

Hong-Yu, Li · Wang, Min · Jiang, Xiaoyu · Wu, Zeming · He, Yifang · Yan, Kaowen · Sun, Shuhui · Ma, Shuai · Ji, Zhejun · Wang, Si · Qu, Jing · Zhang, Weiqi · Wei, Taotao · Liu, Guanghui

Nucleic Acids Research 2024

Advantages

RPL22 deficiency significantly delays senescence in hMPCs

RPL22 overexpression accelerates senescence