Spatiotemporally Controlled Degradation
A modular supramolecular chimera platform enabling tissue-specific and temporally controlled protein degradation in vivo.
Liu, Ji · Tianyu, Ma · Li, Lijuan · Zheng, Qizhen · Wang, Ming
Cell 2026
Robust and tissue-specific degradation in multiple species up to non-human primates
Liver and lung specificity
Degradation of ACSL4 mitigates ferroptosis and pulmonary inflammation in acute lung injury model