Kills tumors under hypoxia
An organic unimolecular photosensitive immunostimulant that targets cancer cells, generates reactive oxygen species via a Type I mechanism, disrupts lysosomes, and activates pyroptosis and cGAS-STING pathways to enhance both innate and adaptive immunity.
Zeng, Shuang · Chen, Chen · Zhihan, Guo · Wang, Yang · Liu, Xiaosheng · Li, Xin · Jeong, Hyunsun · Hao, Yifu · Zhou Danhong, · Long, Saran · Wang, Jingyun · Li, Haidong · Peng, Xiaojun · Yoon, Juyoung
Angewandte Chemie - International Edition 2025
Generates reactive oxygen species via Type I photodynamic mechanism even under hypoxic conditions
Effectively treats primary tumors and inhibits metastatic growth