Glycol-Split Heparin Prodrug Nanoparticles

Mitochondria-targeted anti-metastasis

Unlike existing angiogenesis inhibitors, these nanoparticles target the mitochondrial apparatus and disrupt its structure to simultaneously suppress multiple metastasis-related proteins.

Sun, Feng · Hou, Huiwen · Li, Yan · Tang, Wen · Wang, Jie · Lu-Lu, Liu · Fu, Jiali · Zhao, Feiyang · Ling, Peixue · Wang, Fengshan · Tan, Haining

Small 2023

Advantages

Inhibits migration, invasion, and angiogenesis of B16F10 cells in vitro

Suppresses tumor growth and metastasis in B16F10 tumor-bearing mice in vivo

Exhibits efficient anti-angiogenesis properties