Dual pH/GGT unlock
Sequential acidic pH and GGT stimuli trigger a negative-to-positive charge reversal, enabling efficient cellular uptake, deep tumor penetration, and direct nuclear delivery for high localized ROS generation and enhanced PDT with reduced off-target toxicity.
Ling, Bo · Lijiao, Yang · Wang, Chenchen · Dong, Ling · Yang, Yanyun · Wang, Lun · Zhang, Jia · Yuan, Yue
ACS Materials Letters 2024
Significantly and precisely boosted PDT efficacy in GGT-overexpressed tumors
Excellent stability in blood circulation
Direct nucleus delivery of ROS
Robust DNA damage