Trifunctional Sialylation Hydrogel

Selective osteoclast inhibition

A hydrogel that selectively inhibits osteoclast fusion and promotes vascularized bone formation, offering a targeted strategy for osteoporotic bone defect repair.

Tang, Yong · Tan, Jiulin · Zhang, Jie · Cai, Juan · Dai, Qijie · Xu, Jianzhong · Guo, Shuquan · Dou, Ce · Luo, Fei

Advanced Science 2025

Advantages

Osteoclast fusion impeded

Enhanced PDGF-BB secretion

FAK signaling pathway activated