Light-driven DNA tetrahedral amplifier

Integrated precise cancer theranostics

Biosensing is activated by UV light to avoid nonspecific response during delivery, while MOF and DNA tetrahedron synergetically load doxorubicin for integrated highly sensitive detection and chemotherapy in vivo.

Chen, Ling · Sun, Xiaoming · He, Wei · Meng, Xin · Liu, Da · Li, Chengyu

ACS Applied Materials & Interfaces 2023

Advantages

Can distinguish single-base mismatching

Excellent bioimaging competence in live biosystems

Good chemotherapy efficacy in live biosystems