gem-Difluorinated Isoxazoles

One-Step Assembly

Directly combines isoxazole motifs with gem-difluoroalkene units via palladium-catalyzed oxylallylation, yielding structurally diverse gem-difluorinated isoxazole derivatives.

Li, Jianxiao · Wang, Bowen · Xiong, Wenfang · Jiang, Huanfeng

Chemistry - An Asian Journal 2023

Advantages

moderate to good yields

high atom- and step-economy

excellent functional group compatibility