dual-pathway ferroptosis induction
Simultaneously and independently inhibits the SLC7A11/GPX4 antioxidant axis and enhances NCOA4-mediated ferritinophagy degradation of FTH1, inducing ferroptosis and significantly suppressing tumor progression in lung cancer models.
Shi, Xingxing · Liu, Kun · Tian, Yuchang · Junkai, Zhang · Wei, Wensheng · Zhao, Tongbiao
Cell Death Discovery 2025