Cav-1 Targeting Inhibitor

Preserves BBB

Targets Caveolin-1 to reduce tight junction degradation by suppressing MMP2/9 activity, thereby preserving blood-brain barrier integrity and offering a novel strategy for preventing postoperative cognitive dysfunction.

Ding, Weihua · Zhang, Xia · Bao, Xiuxia · Kang, Xianhui · Zhu, Shengmei

Neurochemical Research 2025

Advantages

Restores Tight Junctions

Inhibiting Cav-1 restores expression of Claudin-5 and ZO-1, repairing BBB integrity.

Reduces BBB Permeability

By suppressing MMP2/9, degradation of tight junction proteins is reduced, thereby lowering BBB permeability.

Improves Cognition

Animal experiments show that inhibiting Cav-1 attenuates postoperative cognitive decline.

Elucidates Mechanism

Confirms the Cav-1/MMP2/9 signaling axis in BBB disruption, providing a clear therapeutic target.

Applications

• BBB protection：Preserve BBB integrity by preventing tight junction degradation post-surgery
• Postoperative cognitive dysfunction：Reduce incidence of postoperative cognitive dysfunction and improve patient outcomes
• Neuroinflammation：Suppress neuroinflammation-induced MMP activation to mitigate BBB damage