pH/Hypoxia Dual-Responsive Nanocarrier

Tumor-selective uptake

Achieving synergy of photodynamic therapy and hypoxia-activated chemotherapy to potentially overcome chemoresistance.

Zhang, Zhang · Feng, Jintang · Zhang, Tianzhu · Sun, Chunyang

Frontiers in Bioengineering and Biotechnology 2023

Advantages

Encapsulated photosensitizer Ce6 and hypoxia-activated prodrug TPZ

PDT-boosted hypoxia-activated chemotherapy under 660 nm laser

Prolonged blood circulation and selective tumor cell uptake