98% wound closure in 12 days
pH-responsive ROS modulation switches from biofilm disruption to anti-inflammatory repair, offering a non-antibiotic therapy for MRSA-infected wounds.
Jianan, Li · Bei, Zhongwu · Jian, Hua · Meng, Wang · Yujia, Wei · Qu, Ying · Chu, Bingyang · Yang, Yun · Mo, Dong · Shiyu, Liang · XiCheng, Li · Liu, Qingya · Pan, Meng · Yutong, Qian · Xiaorui, Yu · Qian, Zhiyong · Gao, Xiang · Cheng, Yongzhong
Bioactive Materials 2026
In the mildly acidic infection environment, the copper-based nanozyme promotes localized ROS generation to disrupt MRSA biofilms and enhance antibacterial efficacy, overcoming biofilm-protected antibiotic tolerance.
As the wound environment gradually returns toward neutrality, the system shifts toward ROS scavenging, thereby alleviating oxidative stress and suppressing inflammatory amplification.
In vivo, the dressing significantly improved neovascularization and advanced tissue remodeling, as shown by enhanced collagen deposition and increased new vessel formation in histological analyses.