hsa_circ_0005882 CircRNA

Suppresses NPC proliferation

This circRNA acts as a sponge for miR-654-3p, regulated by YTHDF2, to inhibit nasopharyngeal carcinoma cell proliferation.

Xu, Wang · Aiyu, Ma · Lu, Lu · Yang, Yuzhong · Sun, Yiping · Zhang, Yan · Zheng, Jinhua · Zheng, Xiang

Neoplasma 2026

Specifications

sponge for miR-

{'zh': '-3', 'en': '-3'} p

Advantages

Strongly suppresses tumor growth

Overexpression of circ_0005882 significantly reduces the proliferative capacity of nasopharyngeal carcinoma cells, indicating its potential as a tumor suppressor.

Regulated by m6A switch

The m6A reader YTHDF2 binds to circ_0005882 and promotes its degradation, providing an upstream switch to control its expression.

Sponges oncogenic miRNA

circ_0005882 sponges miR-654-3p, relieving its inhibition of downstream target genes to suppress NPC proliferation.

Applications

• Tumor suppression：Overexpression of circ_0005882 inhibits proliferation of NPC cells.
• RNA regulation：circ_0005882 is regulated by m6A and forms a ceRNA network with miR-654-3p.
• Non-coding RNA therapeutics：It can serve as a non-coding RNA therapeutic by sponging miR-654-3p to exert antitumor effects.